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MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells

Pei-Ling Hsieh1, Yi-Wen Liao2,3, Martin Pichler4

  • 1Department of Anatomy, School of Medicine, China Medical University, Taichung 404, Taiwan.

Cancers
|February 8, 2020
PubMed

Insights

Non-coding RNAs (ncRNAs) are key regulators of oral cancer stemness, influencing tumor initiation and metastasis. Understanding these ncRNAs offers potential diagnostic and therapeutic strategies for oral cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Oral cancer, a type of head and neck squamous cell carcinoma, is a significant global health concern.
  • Cancer stem cells (CSCs) are implicated in oral cancer initiation, metastasis, and recurrence.
  • Non-coding RNAs (ncRNAs) are increasingly recognized for their role in maintaining cancer stemness.

Purpose of the Study:

  • To review the role of ncRNAs in regulating oral cancer stemness.
  • To summarize the potential theranostic applications of ncRNAs in oral cancer.
  • To highlight the translation of ncRNA research into clinical practice.

Main Methods:

  • Literature review of existing studies on ncRNAs and oral cancer stemness.
  • Analysis of the impact of ncRNAs on oral cancer initiation, metastasis, and recurrence.
  • Evaluation of ncRNAs as diagnostic markers and therapeutic targets.

Main Results:

  • Aberrant expression of ncRNAs is linked to the acquisition and maintenance of cancer stemness in oral cancer.
  • ncRNAs play crucial roles in oral tumorigenesis and progression.
  • Dysregulated ncRNAs show potential as biomarkers and therapeutic targets for oral cancer.

Conclusions:

  • ncRNAs are critical regulators of oral cancer stemness with significant theranostic potential.
  • Further understanding of ncRNAs in oral cancer will aid clinical translation.
  • Targeting ncRNAs may offer novel therapeutic strategies for oral cancer treatment.
Keywords:
cancer stem cellshead and neck squamous cell carcinomanon-coding RNAsoral cancer

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