Related Experiment Video
Updated: Aug 6, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
Gene for parathyroid hormone-like peptide is on rat chromosome 2
G N Hendy1, A Y Sakaguchi, T Yasuda
1Department of Medicine, McGill University, Montreal, PQ, Canada.
Abstract:
Parathyroid hormone-like peptide (PLP) is thought to be a mediator of hypercalcemia in both human and rodent malignancies. A rat PLP cDNA was used as a hybridization probe in Southern blot analysis of DNAs isolated from a panel of rat-mouse somatic cell hybrids. The single-copy gene for PLP was assigned to rat chromosome 2, whereas the rat parathyroid hormone (PTH) gene has previously been assigned to rat chromosome 1. Consequently, despite significant amino-terminal homology between PLP and PTH the genes encoding these peptides in the rat as well as human species have discrete chromosomal localizations.
Related Concept Videos
Cell Specific Gene Expression
The Ras Gene
Ras is a superfamily...
Receptor Tyrosine Kinases
The Ras Gene
Ras is a superfamily...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

