Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Flow02:39

Gene Flow

37.3K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
37.3K
Frequency-dependent Selection01:21

Frequency-dependent Selection

23.0K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.0K
Genetic Drift03:33

Genetic Drift

42.7K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
42.7K
Limits to Natural Selection01:38

Limits to Natural Selection

33.8K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
33.8K
Types of Selection01:46

Types of Selection

43.7K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
43.7K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

61.5K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
61.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co(II), Cu(II), and Ni(II) Coordination Complexes: Synthesis, Characterization, Experimental, and Computational Study on Potential Antiplasmodial Activity.

ChemMedChem·2026
Same author

Synthesis, Characterization, and Anti-Plasmodium falciparum Activity of a New Copper(II) Complex Containing 2-(Tert-Butoxy)-6-(1H-imidazol-1-yl)pyridine.

ChemMedChem·2026
Same author

Polygenic predisposition modifies the associations of fish oil supplementation with circulating omega-3 fatty acids: a cross-sectional gene-diet interaction study in UK Biobank.

medRxiv : the preprint server for health sciences·2026
Same author

Associations of vegetarianism with circulating lipids across varying genetic capacity: a cross-sectional Polygenic Score-by-Vegetarianism interaction study in UK Biobank.

medRxiv : the preprint server for health sciences·2026
Same author

A variance QTL approach to uncover gene-fish oil supplement interaction loci for 14 circulating unsaturated fatty acid traits.

medRxiv : the preprint server for health sciences·2026
Same author

African-enriched SLC39A10 (ZIP10) missense variants differentially affect cellular zinc homeostasis and associate with health-related traits.

Genes & nutrition·2026

Related Experiment Video

Updated: Dec 29, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.3K

Admixture-enabled selection for rapid adaptive evolution in the Americas.

Emily T Norris1,2,3, Lavanya Rishishwar1,2,3, Aroon T Chande1,2,3

  • 1School of Biological Sciences, Georgia Institute of Technology, 950 Atlantic Drive, Atlanta, GA, 30332, USA.

Genome Biology
|February 8, 2020
PubMed
Summary
This summary is machine-generated.

Human population admixture accelerates evolution by introducing new genetic variants. This study shows admixture enables rapid adaptation, particularly in immune system genes, driving human evolution.

Keywords:
AdmixtureGenetic ancestryPolygenic traitsPopulation genomicsPositive selectionRapid adaptive evolution

More Related Videos

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
06:03

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Published on: September 20, 2016

15.1K
Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases TALENs
07:42

Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases TALENs

Published on: June 20, 2016

8.7K

Related Experiment Videos

Last Updated: Dec 29, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.3K
Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
06:03

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Published on: September 20, 2016

15.1K
Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases TALENs
07:42

Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases TALENs

Published on: June 20, 2016

8.7K

Area of Science:

  • Human genetics
  • Evolutionary biology
  • Population genomics

Background:

  • Admixture, the exchange of genetic material between previously isolated populations, is a common phenomenon in human history.
  • This process can introduce novel genetic variants (haplotypes) into populations, potentially facilitating rapid adaptation.
  • The study investigates admixture's role in adaptive evolution using genomic data from Latin American populations.

Purpose of the Study:

  • To test the hypothesis that admixture enables rapid adaptive evolution in human populations.
  • To identify genetic loci and traits influenced by admixture-enabled selection.
  • To understand the mechanisms driving human adaptation through admixture.

Main Methods:

  • Analysis of whole genome sequences from admixed Latin American populations (Colombia, Mexico, Peru, Puerto Rico).
  • Screening for loci with significant ancestry enrichment or depletion compared to genome-wide frequencies.
  • Utilizing a combined evidence approach across multiple populations and polygenic traits.

Main Results:

  • Identified African ancestry enrichment at the major histocompatibility locus (chromosome 6), suggesting selection for enhanced immune response.
  • Found evidence of positive selection in specific human leukocyte antigen (HLA) genes prior to admixture.
  • Observed admixture-enabled polygenic selection related to inflammation, blood metabolites, and immune system functions.

Conclusions:

  • Admixture is a fundamental mechanism driving rapid adaptive evolution in human populations.
  • The findings support the role of admixture in shaping human genetic diversity and adaptation.
  • Admixture-enabled selection, especially in immune-related genes, is a key evolutionary force.