Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central and peripheral haemodynamic changes after alcohol ingestion.

H Kelbaek1, S Fløistrup, T Gjørup

  • 1Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark.

Alcohol and Alcoholism (Oxford, Oxfordshire)
|January 1, 1988
PubMed
Summary

Acute alcohol intake impairs left ventricular contractility, increasing heart rate and cardiac output. Hangover effects include sustained elevated cardiac output and reduced peripheral resistance despite normalized forearm blood flow.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drop-out from cardiovascular magnetic resonance in a randomized controlled trial of ST-elevation myocardial infarction does not cause selection bias on endpoints.

Clinical research in cardiology : official journal of the German Cardiac Society·2017
Same author

Assessment of coronary artery disease using coronary computed tomography angiography in patients with aortic valve stenosis referred for surgical aortic valve replacement.

International journal of cardiology·2012
Same author

Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial.

International journal of cardiology·2009
Same author

WITHDRAWN: Quantitative Analysis of Dobutamine-Atropine Stress Echocardiography.

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology·2006
Same author

Percutaneous treatment of coronary bifurcation lesions: a novel "extended Y" technique with complete lesion stent coverage.

Heart (British Cardiac Society)·2006
Same author

Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function.

Heart (British Cardiac Society)·2004

Area of Science:

  • Cardiovascular Physiology
  • Alcohol Metabolism

Background:

  • Alcohol consumption significantly impacts physiological functions.
  • Understanding acute alcohol's cardiovascular effects is crucial for public health.

Purpose of the Study:

  • To investigate central and peripheral hemodynamic changes following alcohol ingestion.
  • To assess the cardiovascular and circulatory responses during acute intoxication and early hangover phases.

Main Methods:

  • Radionuclide cardiography and strain gauge plethysmography were employed.
  • Hemodynamic parameters including heart rate, cardiac output, and forearm blood flow were measured.
  • Serum ethanol levels were monitored at 1 and 8 hours post-ingestion.

Main Results:

Related Experiment Videos

  • Alcohol ingestion led to increased heart rate (12-19%) and cardiac output (24-23%) within 1-8 hours.
  • Left ventricular ejection fraction initially decreased by 5% but later increased by 4%.
  • Forearm blood flow increased by 140% at 1 hour, returning to baseline by 8 hours, while total peripheral resistance decreased by 25%.

Conclusions:

  • Acute alcohol intoxication impairs left ventricular contractility but increases cardiac output via tachycardia.
  • Sustained elevated cardiac output during the hangover phase is linked to tachycardia and reduced peripheral resistance.
  • Sympathetic nervous activity, measured by plasma norepinephrine, was not significantly altered.