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Cellular DNA pattern, S-phase frequency and survival in papillary thyroid cancer
J Hrafnkelsson1, O Stål, S Eneström
1Department of Oncology, Regional Hospital, Linköping, Sweden.
Acta Oncologica (Stockholm, Sweden)
|January 1, 1988
Summary
DNA aneuploidy in papillary thyroid cancer indicates a poorer prognosis, particularly in older patients and those with advanced disease. High s-phase frequency also correlates with less favorable outcomes.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Papillary thyroid carcinoma is the most common type of thyroid cancer.
- Prognostic factors for papillary thyroid cancer are crucial for treatment planning.
- Cellular DNA content and proliferation markers may influence patient outcomes.
Purpose of the Study:
- To investigate the prognostic significance of DNA content and S-phase fraction in papillary thyroid cancer.
- To identify independent prognostic factors in a long-term patient cohort.
Main Methods:
- Retrospective analysis of 150 papillary thyroid cancer patients diagnosed between 1955-1984.
- Flow cytometric analysis of archival paraffin-embedded tumor tissue.
- Multivariate analysis using the Cox proportional hazards model.
Main Results:
- DNA aneuploidy was detected in 12% of tumors, more frequent in elderly patients, poorly differentiated tumors, males, and those with high S-phase fraction.
- Independent prognostic factors identified: aneuploidy, age at diagnosis, lymph node metastasis, and extrathyroidal extension.
- High S-phase frequency ( > 2.5%) was associated with a less favorable prognosis.
Conclusions:
- DNA aneuploidy and high S-phase frequency are significant indicators of poor prognosis in papillary thyroid cancer.
- These cellular characteristics, along with clinical factors, aid in predicting patient outcomes.
- Findings support the use of flow cytometry in assessing papillary thyroid cancer aggressiveness.