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PYY, a Therapeutic Option for Type 2 Diabetes?

Claudia Guida1, Reshma Ramracheya1

  • 1Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

Clinical Medicine Insights. Endocrinology and Diabetes
|February 8, 2020
PubMed

Insights

Metabolic surgery rapidly reverses diabetes through gut hormones like peptide tyrosine tyrosine (PYY). PYY shows promise for new diabetes treatments, independent of weight loss.

Area of Science:

  • Endocrinology
  • Metabolic Surgery
  • Diabetes Research

Background:

  • Metabolic surgery effectively reverses type 2 diabetes in humans.
  • Weight-independent mechanisms drive these metabolic improvements.
  • Gut hormones, including GLP-1 and PYY, are implicated in post-surgical recovery.

Purpose of the Study:

  • To review the role of peptide tyrosine tyrosine (PYY) in the metabolic benefits of bariatric surgery.
  • To highlight PYY's contribution to improved pancreatic islet function and survival.
  • To advocate for PYY-based therapeutic strategies for diabetes treatment.

Main Methods:

  • Literature review of current knowledge on PYY and metabolic surgery.
  • Analysis of evidence linking PYY to appetite regulation and islet function.
  • Synthesis of recent advancements in PYY research for diabetes.

Main Results:

  • Peptide tyrosine tyrosine (PYY) significantly contributes to the metabolic improvements following bariatric surgery.
  • PYY influences appetite regulation and enhances pancreatic islet secretory properties.
  • Evidence supports PYY's role in islet cell survival and function.

Conclusions:

  • PYY is a key mediator of diabetes remission after metabolic surgery.
  • PYY's multifaceted effects on metabolism and islet function are crucial.
  • Novel therapies targeting PYY offer a promising avenue for diabetes treatment.
Keywords:
PYYbariatric surgerydiabetespancreatic islets

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