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Late clinical outcomes of aortic valve replacement with Carpentier-Edwards pericardial valves

Hyoung Woo Chang1, Wook Sung Kim2, Joong Hyun Ahn3

  • 1Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.

Journal of Thoracic Disease
|February 8, 2020
PubMed

Insights

The Carpentier-Edwards Perimount valve demonstrated superior long-term survival and event-free rates compared to the Perimount Magna valve in aortic valve replacement. Magna valves showed lower pressure gradients post-surgery.

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Clinical Outcomes Research

Background:

  • Aortic valve replacement (AVR) is a critical procedure for managing aortic valve disease.
  • Comparing long-term clinical and hemodynamic outcomes of different prosthetic valves is essential for surgical decision-making.

Purpose of the Study:

  • To compare the long-term clinical and hemodynamic outcomes of AVR using Carpentier-Edwards Perimount (Perimount) and Perimount Magna (Magna) valves.
  • To evaluate survival rates and identify factors influencing outcomes after AVR.

Main Methods:

  • A cohort of 430 patients undergoing AVR between 1998-2013 with either Perimount (n=58) or Magna (n=372) valves were analyzed.
  • Multivariable and inverse probability of treatment weight (IPTW) analyses were employed to assess outcomes.

Main Results:

  • The Perimount group exhibited significantly better 8-year overall survival (90%±4% vs. 76%±4%, P=0.02) and event-free survival (P=0.006) compared to the Magna group.
  • Perimount valve use was identified as a protective factor for overall survival (P=0.009).
  • The Magna group showed significantly lower aortic valve pressure gradients at one and five years postoperatively.

Conclusions:

  • The Perimount valve is associated with superior long-term overall and event-free survival following AVR.
  • While the Magna valve may reduce pressure gradients, its use was linked to poorer survival outcomes.
  • Further large-scale studies are warranted to validate these findings.
Abstract

Keywords:
Prosthesisaortic stenosis (AS)aortic valve replacementhemodynamicssurvival

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