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Patient-specific reference values for objective physical function tests: data from the Osteoarthritis Initiative.

Matthew S Harkey^1,2, Lori Lyn Price^3,4, Kieran F Reid⁵

¹Division of Rheumatology, Allergy, & Immunology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA, 02111, USA. mharkey@tuftsmedicalcenter.org.

Clinical Rheumatology

|February 8, 2020

Summary

This summary is machine-generated.

This study establishes sex-specific reference values for objective physical function in individuals with or at risk for knee osteoarthritis (KOA), considering age, severity, and BMI. These values aid in interpreting physical function performance for better patient care.

Keywords:

Chair stand KL grade Knee osteoarthritis Muscle strength Obesity Walking speed

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The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation

The Lower Body Positive Pressure Treadmill for Knee Osteoarthritis Rehabilitation

Published on: July 22, 2019

Area of Science:

Orthopedics
Gerontology
Biomedical Engineering

Background:

Knee osteoarthritis (KOA) significantly impacts physical function.
Objective physical function measures are crucial for assessing KOA progression and treatment efficacy.
Existing reference values often lack granularity regarding patient-specific factors like sex, age, BMI, and KOA severity.

Purpose of the Study:

To establish sex-specific reference values for objective physical function tests.
To stratify these reference values by age, radiographic KOA severity (Kellgren-Lawrence grade), and body mass index (BMI).
To provide a tool for improved interpretation of physical function in individuals with or at risk for KOA.

Main Methods:

Utilized data from 3860 Osteoarthritis Initiative participants.
Quantified objective physical function using 20-m walk speed, chair-stand speed, 400-m walk time, and knee strength.
Generated reference values as percentiles across combined subsets of sex, age, KL grade, and BMI.

Main Results:

Created comprehensive reference value tables for objective physical function.
An interactive reference value table was developed for clinical and research use.
Identified clinically relevant sex-based differences in 20-m walk speed and knee extension strength across various subgroups.

Conclusions:

Sex-specific reference values, stratified by age, KOA severity, and BMI, enhance the interpretation of physical function.
These patient-centered reference values facilitate a more accurate assessment of an individual's functional status.
The interactive table offers a practical tool for clinicians and researchers to evaluate patient performance against relevant benchmarks.