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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Updated: Dec 29, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Gastric Tumor Microenvironment.

Armando Rojas¹, Paulina Araya², Ileana Gonzalez²

¹Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, Talca, Chile. arojasr@ucm.cl.

Advances in Experimental Medicine and Biology

|February 8, 2020

Summary

This summary is machine-generated.

Gastric cancer

Keywords:

Cancer-associated fibroblasts Chronic inflammation Exosomes Extracellular matrix Gastric cancer Helicobacter pylori MicroRNAs Tumor microenvironment Tumor-associated macrophages Tumor-associated mast cells Tumor-infiltrating neutrophils

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Published on: September 20, 2016

Area of Science:

Oncology
Cancer Biology
Immunology

Background:

Gastric cancer exhibits a unique tumor microenvironment (TME) that promotes tumor progression and metastasis.
Genetic and epigenetic alterations drive complex interactions within the TME.

Purpose of the Study:

To review the key cellular and extracellular components of the gastric cancer TME.
To highlight the molecular mechanisms underlying cell-cell communication within this microenvironment.

Main Methods:

Literature review focusing on cellular players and molecular crosstalk in gastric cancer TME.
Analysis of genetic and epigenetic mechanisms governing TME interactions.

Main Results:

Identified key contributors to the gastric cancer TME: cancer-associated fibroblasts, bone marrow-derived cells, tumor-associated macrophages, and tumor-infiltrating neutrophils.
Highlighted the dynamic extracellular matrix and its role in TME regulation.
Emphasized the critical role of molecular crosstalk in determining tumor fate.

Conclusions:

The gastric cancer TME is a complex, dynamic ecosystem.
Understanding the intricate crosstalk between TME components is crucial for targeting gastric cancer progression.