Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

1.9K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
1.9K
Metastasis02:30

Metastasis

6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter to the Editor Regarding "Outcomes of Interventions to Salvage the Jailed Profunda Femoris in Recurrent Limb-Threatening Critical Ischemia".

Annals of vascular surgery·2026
Same author

Letter to the Editor: Comment on "Stent Diameter, Not Sex, Is Predictive of Reintervention After Common Iliac Artery Stenting".

Annals of vascular surgery·2026
Same author

Letter to the Editor: Comment on "Stent Diameter, Not Sex, Is Predictive of Reintervention After Common Iliac Artery Stenting".

Annals of vascular surgery·2026
Same author

Letter to the Editor Regarding: "Alterations in Arterial Stiffness and Cardiac Function Following Complex Endovascular Repair of Pararenal and Thoracoabdominal Aortic Aneurysms".

Annals of vascular surgery·2026
Same author

Insights Into Rectal Cancer Immunology.

Diseases of the colon and rectum·2026
Same author

Toward a Neoadjuvant Immune Chemoradiotherapy in Rectal Cancer.

Diseases of the colon and rectum·2026

Related Experiment Video

Updated: Dec 29, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.5K

Appendix Tumor Microenvironment.

Luca Roncati1, Paolo Gasparri1, Graziana Gallo1

  • 1Department of Medical and Surgical Sciences, Institute of Pathology, University Hospital of Modena, Modena (MO), Italy.

Advances in Experimental Medicine and Biology
|February 8, 2020
PubMed
Summary
This summary is machine-generated.

Appendix tumors share features with colorectal neoplasms, with a higher incidence of carcinoids. The appendix tumor microenvironment (TME) involves immune cells and stroma, with tumor-infiltrating lymphocytes potentially improving prognosis.

Keywords:
AdenocarcinomaAppendixBriskCancerCarcinoidHigh-grade large B-cell lymphomaImmune scoreLymphomaMALTomaMucoceleNeuroendocrine tumorNon-briskSignet-ring cell carcinomaTumor microenvironmentTumor-infiltrating lymphocytes (TILs)

More Related Videos

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.8K
Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
08:42

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

1.7K

Related Experiment Videos

Last Updated: Dec 29, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.5K
A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.8K
Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
08:42

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

1.7K

Area of Science:

  • Oncology
  • Pathology
  • Immunology

Background:

  • Appendix tumors exhibit pathological similarities to colorectal neoplasms.
  • Carcinoids are relatively common in the appendix due to abundant enteroendocrine cells.
  • Hodgkin and non-Hodgkin lymphomas can arise from the appendix's mucosal-associated lymphatic tissue.

Purpose of the Study:

  • To describe the pathological features of appendix tumors.
  • To analyze the appendix tumor microenvironment (TME).
  • To investigate the role of immune cells, particularly tumor-infiltrating lymphocytes, in appendix carcinoids.

Main Methods:

  • Pathological examination of appendix tumor specimens.
  • Histological analysis of tumor microenvironment components (cellular and noncellular).
  • Evaluation of immune cell infiltration, specifically tumor-infiltrating lymphocytes.

Main Results:

  • Appendix tumors share features with colorectal neoplasms, with a notable prevalence of carcinoids.
  • The appendix TME comprises cellular (immune cells) and noncellular (stroma) components.
  • Tumor-infiltrating lymphocytes in carcinoids can exhibit a brisk reaction, potentially correlating with a favorable prognosis.

Conclusions:

  • The appendix TME is a complex system with immunological, mechanical, and metabolic roles.
  • Neo-lymphangiogenesis is a significant feature within the appendix TME.
  • Distinguishing active immune responses from inflammation or tumor complications is crucial for prognosis.