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Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics
Cristiano Grisi do Nascimento1, Gabrielle Bragaglia2, Sandra Barioni Toma2
1Graduate Program in Science, Technology and Innovation in Agriculture, Federal Rural University of Rio de Janeiro (UFRRJ), Seropédica, Brazil.
Journal of Veterinary Pharmacology and Therapeutics
|February 8, 2020
Summary
A new injectable eprinomectin (EPM) formulation effectively controlled cattle ticks (Rhipicephalus microplus) with over 95% efficacy. This study evaluated its pharmacokinetics and efficacy, offering a new control option for Brazilian cattle farmers.
Area of Science:
- Veterinary Parasitology
- Pharmacokinetics
- Animal Health
Background:
- Rhipicephalus microplus is a significant cattle ectoparasite, causing substantial economic losses in Brazil.
- Effective and safe control strategies for cattle ticks are crucial for sustainable livestock production.
Purpose of the Study:
- To evaluate the pharmacokinetic profile of a novel injectable eprinomectin formulation (Voss Performa®).
- To assess the efficacy of this new eprinomectin formulation against Rhipicephalus microplus infestations in cattle.
Main Methods:
- Subcutaneous administration of eprinomectin at 200 μg/kg in a single dose.
- Efficacy evaluation through field and stall tests on naturally and artificially infested cattle.
- Pharmacokinetic parameter estimation (Cmax, Tmax, T1/2, AUC0-t, AUC0-∞).
Main Results:
- The injectable eprinomectin formulation demonstrated efficacy greater than 95% in controlling Rhipicephalus microplus.
- Key pharmacokinetic parameters were determined: Cmax (47.15 ± 22.20 ng/ml), Tmax (1.33 ± 0.492 days), T1/2 (2.96 ± 1.212 days), AUC0-t (228.08 ± 57.30 ng·day/ml), and AUC0-∞ (240.50 ± 58.44 ng·day/ml).
Conclusions:
- The new injectable eprinomectin formulation is highly effective against cattle ticks.
- This formulation presents a valuable alternative for Rhipicephalus microplus control in Brazilian cattle.
