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Updated: Dec 29, 2025

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Granuloma annulare after Botulonium toxin A injection: A rare association
Kamran Balighi1, Kambiz Kamyab2, Arghavan Azizpour1
1Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background:
Botulinum toxin is generally considered safe and has been used in constantly expanded cosmetic and therapeutic indications. However, long-term side effects such as granulomatous reactions have been associated with this drug.
Aims:
We aim to evaluate a rare reaction to Botulonium toxin A injection.
Patients/Methods:
A 44-year-old woman, developed annular plaques eleven months after botulinum toxin A injection for the correction treatment of wrinklesglabellar rhytides.
Results:
Histopathological examination revealed granuloma annulare formation. Clinical and biological investigations were negative, ruling out the hypothesis of systemic sarcoidosis. Triamcinolone acetonide injection was followed by a regression of the plaques.
Conclusion:
There are previous reports in the literature of sarcoidal and foreign body granuloma at the sites of injection of botulinum toxin A injection. To our knowledge this is the first report of granuloma annulare occurrence after botulinum toxin A injection.
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