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Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

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A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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A Murine Model of Subarachnoid Hemorrhage
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[Hemorrhagic moyamoya disease].

V Angelozzi1, C Germay1, A Gilbert1

  • 1Service des Urgences, CHU Liège, Belgique.

Revue Medicale De Liege
|February 8, 2020
PubMed
Summary

Moyamoya disease, a rare cerebrovascular condition, often presents as stroke or hemorrhage. This case highlights a young patient diagnosed with a brain hemorrhage, emphasizing the need for timely diagnosis and management of this condition.

Keywords:
Brain hemorragheStrokeMoyamoya disease

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Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroscience

Background:

  • Moyamoya disease is a rare, progressive cerebrovascular disorder characterized by stenosis of the terminal portion of the internal carotid arteries and the proximal portions of the anterior and middle cerebral arteries.
  • It typically affects children and young adults, leading to ischemic events (stroke) or hemorrhagic events (brain hemorrhage).

Observation:

  • This report details the case of a young patient who experienced a sudden loss of consciousness.
  • The patient was subsequently diagnosed with a brain hemorrhage, a known but less common presentation of Moyamoya disease.

Findings:

  • Cerebral angiography remains the definitive diagnostic tool for Moyamoya disease, visualizing the characteristic "puff of smoke" appearance.
  • The diagnostic confirmation in this case relied on established imaging modalities to identify the underlying vasculopathy.

Implications:

  • This case underscores the importance of considering Moyamoya disease in the differential diagnosis of young individuals presenting with spontaneous intracranial hemorrhage.
  • Early diagnosis and appropriate therapeutic strategies, ranging from conservative management to surgical revascularization, are crucial for improving patient outcomes and preventing recurrent neurological events.