Localized bullous pemphigoid recurring at different sites: two case reports

Area of Science:

• Dermatology
• Autoimmune Blistering Diseases

Background:

• Localized bullous pemphigoid is a rare variant of bullous pemphigoid, often presenting on specific body areas like legs, palms, or soles.
• Lesions may appear on trauma-affected sites and can either remain localized or generalize.
• Rarely, lesions can recur at new sites after initial healing.

Purpose of the Study:

• To investigate the clinical course of patients diagnosed with localized bullous pemphigoid.
• To highlight the potential for distant recurrence in localized bullous pemphigoid cases.

Main Methods:

• Case report detailing two instances of localized bullous pemphigoid with distant recurrence.
• Review of patient history, lesion presentation, and treatment outcomes.

Main Results:

• Case 1: Localized bullous pemphigoid developed in a patient after mucous membrane pemphigoid improvement, treated successfully with topical corticosteroids.
• Case 2: An elderly male developed localized bullous pemphigoid on his leg following trauma, later experiencing recurrence on palms and soles, responsive to oral prednisolone.

Conclusions:

• Localized bullous pemphigoid exhibits a variable clinical course.
• Extended patient monitoring is essential for managing localized bullous pemphigoid due to unpredictable recurrence patterns.