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Cadaver Nerve Grafts: Past, Present and Future.

Jordi Puente-Espel1, Jeremy Chang2, Xiangxia Liu1

  • 1From the Department of Plastic Surgery.

Annals of Plastic Surgery
|February 8, 2020
PubMed
Summary

Cadaver nerve grafts (CNG) offer a solution for extensive nerve defects when autografts are unavailable, avoiding donor site morbidity. This review explores CNG indications, benefits, drawbacks, and future applications in nerve reconstruction.

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Area of Science:

  • Neurosurgery
  • Regenerative Medicine
  • Biomaterials

Background:

  • Nerve grafts are crucial for reconstructing nerve defects exceeding 1 cm.
  • Autografts, the standard, risk donor site morbidity and are limited in pediatric cases.
  • Reconstructive surgeons face challenges with extensive nerve damage and limited donor nerve availability.

Purpose of the Study:

  • To review the use of cadaver nerve grafts (CNG) in nerve reconstruction.
  • To discuss indications, advantages, and disadvantages of CNG.
  • To provide insights into future perspectives of CNG.

Main Methods:

  • Review of existing literature on cadaver nerve grafts.
  • Analysis of clinical indications and outcomes.
  • Case study presentations of real-world applications.

Main Results:

  • Cadaver nerve grafts enable reconstruction of large nerve lesions without host morbidity.
  • CNG present a viable alternative to autografts in specific clinical scenarios.
  • The review details the benefits and limitations of using CNG.

Conclusions:

  • Cadaver nerve grafts are a valuable option for nerve reconstruction, particularly in cases of extensive defects or limited autograft availability.
  • CNG mitigate donor site morbidity associated with autografts.
  • Further research and application of CNG hold promise for advancing nerve repair techniques.