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Ceftolozane/Tazobactam Treatment of Multidrug-resistant Pseudomonas aeruginosa Infections in Children

Leah Molloy1,2, Ibrahim Abdulhamid2,3,4, Ruma Srivastava2,3,5

  • 1From the Department of Pharmacy.

The Pediatric Infectious Disease Journal
|February 8, 2020
PubMed

Insights

Ceftolozane/tazobactam effectively treated multidrug-resistant Pseudomonas aeruginosa infections in pediatric patients. Most patients achieved clinical cure with manageable adverse events like transaminitis and neutropenia.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Stewardship

Background:

  • Multidrug-resistant Pseudomonas aeruginosa poses a significant threat in pediatric populations.
  • Limited treatment options exist for these challenging infections.

Purpose of the Study:

  • To evaluate the clinical use, safety, and effectiveness of ceftolozane/tazobactam in pediatric patients.
  • To assess outcomes for infections caused by multidrug-resistant Pseudomonas aeruginosa.

Main Methods:

  • Retrospective case series of 13 pediatric patients (3 months to 19 years).
  • Patients received ceftolozane/tazobactam for multidrug-resistant Pseudomonas aeruginosa infections.
  • Clinical outcomes and adverse events were documented.

Main Results:

  • Clinical cure was achieved in 12 out of 13 patients (92.3%) after initial treatment.
  • Adverse drug events, including transaminitis and neutropenia, were observed in 2 patients.
  • Adverse events resolved upon dose reduction, indicating a manageable safety profile.

Conclusions:

  • Ceftolozane/tazobactam demonstrates promising clinical effectiveness for multidrug-resistant Pseudomonas aeruginosa infections in pediatric patients.
  • The safety profile appears manageable, with adverse events responding to dose adjustments.
  • Further research is warranted to confirm these findings in larger cohorts.

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