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THE RAP STUDY, REPORT TWO: The Regional Distribution of Macular Neovascularization Type 3, a Novel Insight Into Its
Bilal Haj Najeeb1, Gabor Deak, Ursula Schmidt-Erfurth
1Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
Purpose:
To explore the regional distribution of macular neovascularization type 3 (MNV3).
Methods:
Seventy-eight eyes of 78 patients were reviewed. We defined the location of each lesion after applying a modified ETDRS grid and the incidence of simultaneous MNV1 or 2. Also, we investigated the distribution of MNV3 at the outline of the foveal avascular zone and when the diameter of foveal avascular zone was less than 325 µm.
Results:
The distribution of MNV3 was 4 lesions (5%) from the center to 500 µm, 72 (92%) from 500 µm to 1500 µm, and 2 (3%) from 1,500 µm to 3000 µm. The distribution in respect of the ETDRS fields was 7 (9%) nasal, 16 (20%) superior, 32 (40%) temporal, and 23 (31%) inferior. No additional MNV1 or 2 were found elsewhere. Most lesions tended to distribute along straight bands radiating from the perifoveal area, mainly in the temporal half (72%). None of the cases had MNV3 at the boundary of the foveal avascular zone. Only five cases had foveal avascular zone diameter of less than 325 µm, the closest lesion was 425 µm away from the center.
Conclusion:
MNV3 lesions are most likely neither symmetrical nor uniformly distributed. They have a higher affinity to distribute radially in the temporal perifoveal area.
Insights
Macular neovascularization type 3 (MNV3) lesions are not uniformly distributed. These MNV3 lesions show a radial distribution preference in the temporal perifoveal area.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Neovascularization
Background:
- Macular neovascularization (MNV) is a key feature in several retinal diseases.
- Understanding the specific distribution patterns of different MNV types is crucial for diagnosis and treatment.
- Macular neovascularization type 3 (MNV3) represents a distinct subtype with potentially unique epidemiological characteristics.
Purpose of the Study:
- To investigate the regional distribution of macular neovascularization type 3 (MNV3) in the macula.
- To determine if MNV3 lesions exhibit a specific spatial pattern or preference.
- To assess the relationship between MNV3 distribution and the foveal avascular zone (FAZ).
Main Methods:
- Retrospective review of 78 eyes from 78 patients diagnosed with MNV3.
- Lesion location was mapped using a modified ETDRS grid.
- Analysis included incidence of simultaneous MNV1 or MNV2 and MNV3 distribution relative to the FAZ outline and diameter.
Main Results:
- MNV3 lesions were predominantly located between 500 µm and 1500 µm from the center (92%).
- Lesions showed a significant temporal distribution (40%), followed by inferior (31%), superior (20%), and nasal (9%).
- Most MNV3 lesions radiated radially in the temporal perifoveal area (72%), with none found at the FAZ boundary.
Conclusions:
- Macular neovascularization type 3 (MNV3) lesions are not symmetrically or uniformly distributed.
- MNV3 demonstrates a clear tendency for radial distribution, particularly in the temporal perifoveal region.
- The findings suggest specific pathogenetic mechanisms influencing MNV3 localization.
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