Tailoring cellular metabolism in lactic acid bacteria through metabolic engineering
Related Experiment Video
Updated: Dec 29, 2025

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
Published on: February 21, 2025
Anshula Sharma1, Gaganjot Gupta1, Tawseef Ahmad1
1Department of Biotechnology, Punjabi University, Patiala 147002, India.
Abstract:
Metabolic engineering combines approaches of synthetic and systems biology for tailoring the existing and creating novel biosynthetic metabolic pathways in the desired industrial microorganisms for production of biofuels, bio-materials and environmental applications. Lactic acid bacteria (LAB) are gaining attention worldwide due to their extensive utilization in food, fermentation and pharmaceutical industries owing to their GRAS status. Well-elucidated genetics and regulatory control of central metabolism make them potential candidates for the production of industrially valuable metabolites. With the recent advancements in metabolic engineering strategies, genetic manipulation and tailoring of cellular metabolism is being successfully carried out in various LAB strains as they are providing highly efficient and industrially competitive robust expression systems. Thus, this review presents a concise overview of metabolic engineering strategies available for the comprehensive tailoring of lactic acid bacterial strains for large-scale production of industrially important metabolites.
More Related Videos
Related Concept Videos
Microbial Fermentation
Other Glycolytic Pathways
Biosynthesis in Bacteria
Inducible Operons: lac Operon
Lipid Catabolism
Amino Acid Catabolism

