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Ins(10;19) in an endometrial stromal sarcoma
P Dal Cin1, J Talcott, J Abrams
1Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Cancer Genetics and Cytogenetics
|November 1, 1988
Summary
A rare uterine tumor, low-grade endometrial stromal sarcoma, was identified in a patient with lung hamartomata. Cytogenetic analysis revealed a unique chromosome 19 insertion into chromosome 10.
Area of Science:
- Gynecologic Oncology
- Cancer Cytogenetics
- Tumorigenesis
Background:
- Mesenchymal cystic hamartomata are rare benign lung tumors.
- Low-grade endometrial stromal sarcoma (LG-ESS) is a rare malignant uterine neoplasm.
Observation:
- A 37-year-old woman presented with LG-ESS.
- She had a history of bilateral lung hamartomata.
Findings:
- Cytogenetic analysis of the uterine tumor detected an unusual derivative chromosome.
- This involved the insertion of chromosome 19 into chromosome 10 [ins(10;19)(p11;p13q13)].
Implications:
- This specific chromosomal abnormality may be a key genetic driver in LG-ESS.
- Understanding this genetic alteration could aid in diagnosing and treating endometrial stromal sarcoma.
- Further research is needed to explore the link between lung hamartomata and uterine neoplasms.