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The effects of four drug regimens on sister chromatid exchange frequency in patients with lymphomas
T Brown1, A A Dawson, B Bennett
1Department of Genetics and Microbiology, Foresterhill, Aberdeen, Scotland.
Cancer Genetics and Cytogenetics
|November 1, 1988
Abstract:
Patients undergoing first-line chemotherapy after diagnosis of lymphoma have considerable DNA damage in their peripheral blood lymphocytes, using sister chromatid exchange (SCE) frequency as a sensitive indicator. Different drug regimens produce different patterns of changes in SCE frequency. These may be related to their potential to induce second malignancies.