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Trisomy 4 in acute nonlymphocytic leukemia
D E Horsman1, J T Pantzar, D K Kalousek
1Department of Pathology, Cancer Control Agency of British Columbia, Vancouver General Hospital, Canada.
Cancer Genetics and Cytogenetics
|December 1, 1988
Abstract:
Trisomy 4 has recently been identified as a nonrandom chromosomal abnormality associated with acute nonlymphocytic leukemia with myelomonocytic morphology (AML M4). It has been suggested that it may be related to a new type of environmental toxin exposure. During the 1975-1987 period we have detected only one case of simple trisomy 4 in over 1200 patients successfully investigated for hematologic malignancy; this patient was diagnosed as having AML M2 and did not have a history of toxic chemical or drug exposure.