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Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells

Kirti S Prabhu1, Afsheen Raza2, Thasni Karedath3

  • 1Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.

Cancers
|February 9, 2020
PubMed

Insights

Non-coding RNAs play crucial roles in breast cancer development and progression. This review explores the biogenesis, functions, and diagnostic/therapeutic potential of microRNAs and long non-coding RNAs in breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a complex, heterogeneous disease with significant public health impact.
  • Non-coding RNAs (ncRNAs), once dismissed as transcriptional noise, are now recognized for their critical roles in cellular processes.
  • ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are implicated in cancer cell proliferation, invasion, migration, apoptosis, and stemness.

Purpose of the Study:

  • To review the fundamental potential of ncRNAs in breast cancer.
  • To elucidate the biogenesis and functional roles of miRNAs and lncRNAs in breast cancer and breast cancer stem cells.
  • To summarize the potential of ncRNAs as diagnostic and therapeutic agents.

Main Methods:

  • Literature review of current research on non-coding RNAs in breast cancer.
  • Analysis of studies detailing miRNA and lncRNA biogenesis and function.
  • Synthesis of information regarding the oncogenic or tumor-suppressive roles of ncRNAs.

Main Results:

  • ncRNAs are integral regulators of key biological processes in breast cancer.
  • miRNAs and lncRNAs can act as oncogenic drivers or tumor suppressors.
  • ncRNAs are involved in intercellular communication within breast cancer.
  • ncRNAs show promise as diagnostic biomarkers and therapeutic targets.

Conclusions:

  • Non-coding RNAs are pivotal in breast cancer pathogenesis and progression.
  • Understanding ncRNA biogenesis and function is essential for developing novel breast cancer strategies.
  • ncRNAs hold significant potential for early diagnosis and targeted therapy in breast cancer treatment.
Keywords:
biogenesisbreast cancer stem cellslong non-coding RNAmicroRNAtargets

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