Human Long Noncoding RNA Interactome: Detection, Characterization and Function.

Area of Science:

• Genomics
• Molecular Biology
• Biochemistry

Background:

• Recent sequencing reveals extensive genome transcription, with most of it being non-coding RNA (ncRNA).
• Long non-coding RNAs (lncRNAs) are a major class of ncRNA, attracting significant research interest.
• The lncRNA interactome, comprising molecules interacting with lncRNAs, is a focus of current investigation.

Purpose of the Study:

• To review the latest information on the human lncRNA interactome.
• To elucidate the biological functions of lncRNAs through their interactions.
• To present methods for detecting and analyzing lncRNA interactome components.

Main Methods:

• Literature review of recent studies on lncRNA interactome.
• Description of techniques for identifying lncRNA-interacting molecules (nucleic acids, proteins, peptides).
• Analysis of methods for studying the nature of these interactions.

Main Results:

• The lncRNA interactome has been increasingly characterized over the last decade.
• Understanding biomolecule associations with lncRNAs is crucial for their functional elucidation.
• Various methods exist for detecting and analyzing lncRNA interactome components.

Conclusions:

• A comprehensive analysis of the lncRNA interactome is essential for understanding its biological roles.
• The lncRNA interactome may play a significant role in organism development.
• Investigating the lncRNA interactome holds potential for understanding cancer development.