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Updated: Sep 11, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
Sensitivity of normal and neoplastic human renal tubular epithelium to hyperthermia
S Dessureault1, P Brown, T Ghose
1Department of Pathology, Dalhousie University, Halifax, N.S., Canada.
Abstract:
Comparison of the intrinsic thermosensitivity of malignant and normal homologous cells are important in evaluating the therapeutic role of hyperthermia in cancer. However, such comparisons had problems with establishing the origin of cells grown in culture. Using monoclonal antibodies we have shown that human kidney cancer lines, Caki-1 and Caki-2, and a normal human renal epithelium line, NHK-4, originated from proximal convoluted tubular epithelium. The observed order of thermosensitivity was Caki-2 greater than Caki-1 greater than NHK-4.
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