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Simulation of CFU-s kinetics after irradiation
1Hybrid Computation Laboratory, Institute for Social Medicine and Organization of Health Services, Prague, Czechoslovakia.
Cell and Tissue Kinetics
|March 1, 1988
Abstract:
A simulation model of the CFU-s population is used to interpret data from experimental studies of bone marrow recovery after irradiation. The model includes an original hypothesis that the proliferation rate in the CFU-s population depends on the number of DNA-synthesizing CFU-s. It is assumed that the DNA-synthesizing CFU-s produce a factor in the presence of which CFU-s enter the resting state G0 after mitosis and remain there for prolonged periods of time. The model can adequately reproduce complex CFU-s kinetics observed after severe damage caused by irradiation with a unique set of parameters.