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Updated: Dec 29, 2025
A Multi-detection Assay for Malaria Transmitting Mosquitoes
Published on: February 28, 2015
Flagging performance of Sysmex XN-10 haematology analyser for malaria detection
Cécile Dumas1, Pauline Tirard-Collet2, Fanélie Mestrallet3
1Service d'Hématologie Biologique, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France cecile.dumas@chu-lyon.fr.
Aim:
The aim was to assess the flagging performance of Sysmex XN-10 haematology analyser for malaria detection through the parasitic red blood cell ('pRBC') alarm.
Methods:
We retrospectively studied 584 blood samples performed on the Sysmex XN-10 analyser that were tested for malaria. Sensitivity, specificity, positive and negative predictive values, and prevalence were established for the pRBC alarm.
Results:
Sensitivity, specificity, and positive and negative predictive values for the pRBC flag were 7.8%, 100%, 100% and 87.7%, respectively. The prevalence of pRBC flag of 0.026% in the overall population was significantly different from the prevalence of 1.027% in the population tested for malaria.
Conclusions:
Considering the excellent specificity and the low prevalence of the flag in the overall population, we suggest, in case of the presence of pRBC flag, the implementation of a rapid review of the blood smear looking for Plasmodium, mostly if the patient had fever and had not been tested for malaria.
