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Related Experiment Video

Updated: Dec 29, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

MET targeting: time for a rematch.

Jonas P Koch^1,2, Daniel M Aebersold^1,2, Yitzhak Zimmer^1,2

¹Department for BioMedical Research, Inselspital, Bern University Hospital, and University of Bern, 3008, Bern, Switzerland.

|February 9, 2020

Summary

MET, a key protein in cell growth and repair, is implicated in cancer when its signaling is deregulated. MET-targeted therapies show promise for cancer treatment, especially with improved patient stratification in clinical trials.

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Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

MET, a receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene vital for embryonic development, homeostasis, and tissue regeneration.
Dysregulation of MET signaling is implicated in numerous malignancies, driving significant interest in MET-targeting strategies for cancer therapy.

Purpose of the Study:

To summarize the biology of MET and its functions in normal physiology and carcinogenesis.
To provide an overview of MET-targeting strategies and clinical trials, discussing past challenges and future potential.

Main Methods:

Literature review of MET biology, MET-targeting strategies, and clinical trial data.
Analysis of MET's role in normal physiology and cancer development.
Evaluation of clinical trial outcomes and patient stratification approaches.

Main Results:

MET plays a crucial role in normal cellular functions but its aberrant signaling drives cancer progression.
Various MET-targeting therapies have been developed, with mixed results in clinical trials.
Genetic analysis of tumors for precise patient stratification holds promise for enhancing the efficacy of MET-targeted therapies.

Conclusions:

MET-targeted therapy remains a promising avenue for cancer treatment.
Improved patient stratification through genetic analysis, as seen in trials like NCI-MATCH, is crucial for overcoming past setbacks and reviving enthusiasm for MET-targeted treatments.