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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Nucleic Acid-Based Therapies for Atherosclerosis.

Petri Mäkinen1, Anna-Kaisa Ruotsalainen1, Seppo Ylä-Herttuala2,3

  • 1A.I. Virtanen Institute, University of Eastern Finland, Neulaniementie 2, P.O. Box 1627, 70211, Kuopio, Finland.

Current Atherosclerosis Reports
|February 9, 2020
PubMed
Summary

Novel RNA-based therapies, including antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), show promise for treating atherosclerosis by targeting lipid and lipoprotein metabolism. Further clinical studies are needed to confirm their efficacy in larger patient populations.

Keywords:
Antisense oligonucleotideAtherosclerosisNucleic acidRNAsiRNA

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