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Microneedle Array Patch (MAP) Consisting of Crosslinked Hyaluronic Acid Nanoparticles for Processability and
Dae-Sung Kim1, Jun-Tae Choi1, Cheong Bi Kim2
1Department of Bionano Technology and Gachon BioNano Research Institute, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea.
Pharmaceutical Research
|February 9, 2020
Summary
New crosslinked hyaluronic acid nanoparticles (X-linked HA-NPs) enable effective microneedle fabrication for sustained drug delivery. These X-linked HA-NPs demonstrate excellent skin penetration and prolonged release, overcoming limitations of traditional hydrogels.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Crosslinked hyaluronic acid (X-linked HA) hydrogels exhibit low fluidity, hindering microneedle fabrication.
- Traditional microneedles face challenges in achieving sustained drug release and consistent fabrication.
Purpose of the Study:
- To develop microneedles using crosslinked hyaluronic acid nanoparticles (X-linked HA-NPs) for improved microneedle fabrication and sustained drug delivery.
- To evaluate the performance and drug release characteristics of X-linked HA-NP microneedle array patches (X-linked HA-NP-MAPs).
Main Methods:
- Fabrication of microneedle array patches using X-linked HA-NPs.
- In vitro evaluation of puncture performance using porcine skin.
- Assessment of dissolution rate and in vivo drug release in mice using fluorescently labeled dextran.
Main Results:
- X-linked HA-NP-MAPs achieved over 90% puncture performance with consistent nanoparticle size.
- Dissolution rates were comparable to free HA-MAPs.
- In vivo studies showed successful administration and longer drug retention from X-linked HA-NP-MAPs compared to HA-MAPs.
Conclusions:
- X-linked HA-NPs offer biocompatibility, processability for micromolding, and sustained drug release capabilities.
- X-linked HA-NP-MAPs demonstrate successful skin penetration and efficient disintegration, suitable for multi-day drug delivery applications.
