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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Dysphasia is associated with diffusion-weighted MRI abnormalities in patients with transient neurological symptoms

Zejin Jia1, Yangguang Song2, Wenli Hu3

  • 1Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|February 9, 2020
PubMed
Abstract

Insights

Diffusion-weighted imaging (DWI) abnormalities were found in 29.5% of patients experiencing transient neurological symptoms, with dysphasia being a key associated characteristic. The Dawson and Diagnosis of TIA (DOT) scores showed higher predictability for these DWI lesions.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Diffusion-weighted imaging (DWI) abnormalities are crucial for diagnosing transient ischemic attack (TIA).
  • Understanding clinical characteristics of DWI lesions aids early diagnosis and intervention for TIA.

Purpose of the Study:

  • To investigate clinical characteristics associated with acute DWI lesions in patients with transient neurological symptoms.
  • To identify factors predicting DWI lesions and compare the predictive value of TIA scores.

Main Methods:

  • Retrospective analysis of 302 patients with transient neurological symptoms, divided into DWI positive and negative groups.
  • Comparison of clinical characteristics and TIA scores (ABCD2, ABCD3, ABCD3I, Dawson, DOT) between groups.
  • Logistic regression and ROC curve analysis to identify independent factors and compare score predictivity.

Main Results:

  • DWI lesions were present in 29.5% of patients.
  • Dysphasia was significantly associated with DWI lesions (OR 2.226).
  • The DOT score (AUC 0.625) and Dawson score (AUC 0.610) demonstrated higher predictability for DWI lesions.

Conclusions:

  • DWI lesions are detected in a significant proportion of patients with transient neurological symptoms.
  • Dysphasia is a clinical characteristic linked to acute DWI lesions.
  • The DOT and Dawson scores offer valuable predictability for identifying DWI lesions in this patient group.
Keywords:
Acute ischemic lesionsDawson scoreDiffusion-weighted imagingThe Diagnosis of TIA scoreTransient neurological symptoms

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