Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

589
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
589
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

762
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
762
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

564
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
564
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

788
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
788

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interpretable intrusion detection for IoT: a CNN-BiLSTM permutation importance framework for deep feature selection.

Frontiers in big data·2026
Same author

Measuring across modalities: Protophones as acoustic attention-getters in infant object communication.

Infant behavior & development·2026
Same author

Infectious Causes of Acute Febrile Illness in Belize, 2020-2022.

The American journal of tropical medicine and hygiene·2026
Same author

EEG classification for neurological disorders using frequency band deciles.

Scientific reports·2025
Same author

Drug grouping learning for improving evidence-based treatment recommendations.

Computers in biology and medicine·2025
Same author

Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).

BMC infectious diseases·2025

Related Experiment Video

Updated: Dec 29, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.2K

Insulin Recommender Systems for T1DM: A Review.

Joaquim Massana1, Ferran Torrent-Fontbona2, Beatriz López2

  • 1Polytechnical School, Universitat de Girona, Girona, Catalonia, Spain. joaquim.massana@udg.edu.

Advances in Experimental Medicine and Biology
|February 9, 2020
PubMed
Summary
This summary is machine-generated.

This review of 70 papers highlights a need for standardized methods in insulin recommender systems (IRSs) for type 1 diabetes mellitus. Current research often lacks real-world testing and detailed feature information, hindering progress.

Keywords:
Bolus calculatorDiabetesInsulin recommender systemReviewT1DM

More Related Videos

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.1K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.1K

Related Experiment Videos

Last Updated: Dec 29, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.2K
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.1K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.1K

Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Artificial Intelligence in Medicine

Background:

  • Type 1 diabetes mellitus (T1DM) necessitates external insulin management due to non-functional pancreatic beta-cells.
  • Maintaining safe blood glucose (BG) levels is critical for individuals with T1DM.
  • Insulin recommender systems (IRSs) aim to automate and optimize insulin delivery.

Purpose of the Study:

  • To comprehensively review and summarize existing Insulin Recommender Systems (IRSs) for T1DM management.
  • To analyze 70 published works based on key aspects of IRS development and implementation.

Main Methods:

  • Systematic literature review of 70 research papers on IRSs.
  • Analysis focused on recommendation technology, control procedures, hardware, testing, pricing, and outcomes.
  • Comparative assessment of methodologies and reported results.

Main Results:

  • Significant lack of published research combining real-world experimentation with simulation processes.
  • Incomplete reporting of IRS features in a substantial number of publications.
  • Variability in experimental design and result presentation impedes direct comparison of studies.

Conclusions:

  • The field of IRSs for T1DM requires standardized protocols for experimentation and reporting.
  • Establishing common standards is essential for robust comparison analysis and scientific advancement.
  • Further research should prioritize transparent reporting and integrated testing methodologies.