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Peritoneal dialysis-related peritonitis as a risk factor for cardiovascular events

Kirsten S Hepburn1, Kelly Lambert2, Judy Mullan2

  • 1Department or Renal Medicine, Wollongong Hospital, Wollongong, New South Wales, Australia.

Internal Medicine Journal
|February 9, 2020
PubMed

Insights

Peritonitis in peritoneal dialysis (PD) patients did not significantly increase cardiovascular event risk. Rapid treatment may mitigate potential cardiovascular risks associated with PD peritonitis.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Cardiovascular disease (CVD) is the primary cause of mortality in peritoneal dialysis (PD) patients.
  • Infections, including PD peritonitis, are known to elevate the risk of cardiovascular events (CVE).
  • The specific association between PD peritonitis and CVE has not been extensively studied.

Purpose of the Study:

  • To investigate peritonitis as a potential risk factor for cardiovascular events (CVE) in patients undergoing peritoneal dialysis (PD).

Main Methods:

  • A retrospective cohort study was conducted involving adult PD patients from 2001 to 2015.
  • Data on patient characteristics and peritonitis events were sourced from the Australian and New Zealand Dialysis and Transplant registry.
  • Cardiovascular event (CVE) data were captured through ICD-10 coding via data linkage.

Main Results:

  • The study included 211 PD patients; 54% experienced peritonitis, and 30.8% had a CVE.
  • Identified CVE risk factors included cerebrovascular disease, diabetes, coronary artery disease, and age.
  • No significant increase in CVE risk was observed following peritonitis episodes (HR 1.37, 95% CI 0.81-2.32), even after adjusting for other risk factors (HR 1.32, 95% CI 0.78-2.23).

Conclusions:

  • This study found no increased risk of cardiovascular events (CVE) after a peritonitis episode in peritoneal dialysis (PD) patients.
  • The lack of a significant association may be attributed to a small sample size or effective, rapid peritonitis treatment strategies.
  • Further research is warranted to confirm these findings and explore the impact of treatment timeliness on cardiovascular outcomes in PD patients.
Abstract

Keywords:
cardiovascular diseasechronic renal insufficiencyinflammationperitoneal dialysisperitonitis

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