Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microtubules in Signaling01:22

Microtubules in Signaling

2.0K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
2.0K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.9K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.8K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.8K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

4.7K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.7K
Catenins01:23

Catenins

2.9K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.9K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.3K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

College students' cognition and attitude toward medical knowledge education after a global public health event.

Frontiers in public health·2025
Same author

A preliminary study on the clinical characteristics of lacrimal duct obstruction in patients with a history of anterior uveitis.

Frontiers in medicine·2025
Same author

Impact of economic growth patterns on carbon quota allocation by industry in China: extensive or intensive.

Scientific reports·2025
Same author

LINC00704 boosts the immunologic escape of colorectal cancer cells by upregulating TLR4 by binding with miR- 203a- 3p.

European journal of medical research·2025
Same author

Bibliometric and visualized analysis of research hotpots and future prospects in lacrimal duct obstruction disease (1900 to 2024).

International journal of ophthalmology·2025
Same author

Dacryocystitis and canaliculitis secondary to residual of epidural catheter remaining in lacrimal duct for 25 years: a case report and literature review.

International journal of ophthalmology·2024

Related Experiment Video

Updated: Dec 29, 2025

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model
09:53

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model

Published on: March 28, 2025

872

Primary cilia: Versatile regulator in cartilage development.

Fenghua Tao1, Ting Jiang2, Hai Tao1

  • 1Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China.

Cell Proliferation
|February 9, 2020
PubMed
Summary

Primary cilia are essential sensory organelles that regulate cartilage development by responding to mechanical stress and mediating signaling pathways. Understanding their role is key to advancing cartilage research and treating related diseases.

Keywords:
cartilage developmentcartilage tumorigenesismechanical stressosteoarthritisprimary ciliasignalling transduction

More Related Videos

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

10.9K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.7K

Related Experiment Videos

Last Updated: Dec 29, 2025

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model
09:53

Volumetric Imaging and Analysis of Primary Cilia in Musculoskeletal Tissue using the ARL13B-CENTRIN-2 Mouse Model

Published on: March 28, 2025

872
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

10.9K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.7K

Area of Science:

  • Biomedical Science
  • Cell Biology
  • Skeletal Biology

Background:

  • Cartilage, a connective tissue with limited regeneration, is influenced by physical, chemical, and biological factors.
  • Primary cilia are vital sensory organelles regulating signaling transduction and cell activities in various biological processes.
  • These cilia play a critical role in cartilage development, disease progression, and tumorigenesis.

Purpose of the Study:

  • To review the recent advancements in understanding the role of primary cilia in cartilage development.
  • To elaborate on the potential regulatory mechanisms by which primary cilia influence cartilage growth and homeostasis.
  • To highlight the significance of primary cilia research in the context of cartilage biology and pathology.

Main Methods:

  • Literature review of recent scientific publications on primary cilia and cartilage.
  • Analysis of signaling pathways and cellular activities regulated by primary cilia in chondrocytes.
  • Examination of the impact of primary cilia dysfunction on cartilage development and disease.

Main Results:

  • Primary cilia act as crucial mechanosensors, responding to mechanical stress in the cartilage environment.
  • They mediate key signaling pathways, including Hedgehog and Wnt signaling, essential for chondrogenesis.
  • Primary cilia are implicated in regulating the progression of cartilage-related diseases and influencing cartilage tumor formation.

Conclusions:

  • Primary cilia are indispensable for normal cartilage development and function.
  • Their sensory and signaling roles are central to maintaining cartilage homeostasis and responding to environmental cues.
  • Further research into primary cilia mechanisms offers promising therapeutic targets for cartilage disorders and cancer.