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Codon Modification and PAMPs in Clinical AAV Vectors: The Tortoise or the Hare?

J Fraser Wright1

  • 1Department of Pediatrics, Center for Definitive and Curative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|February 9, 2020
PubMed
Abstract

No abstract available in PubMed .

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...

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