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Updated: Dec 29, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Modulation of human endogenous retroviruses -H, -W and -K transcription by microbes
Massimiliano Bergallo1, Ilaria Galliano1, Paola Montanari1
1Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy.
Abstract:
The human endogenous retroviruses (HERVs) are endogenous retroviruses that are inserted into the germ cell DNA of humans over 30 million years ago. Using real-time RT-PCR we describe HERV modulation by commensal microbes in the human gut. Infants, exclusively or predominant breast milk feeding, less than 12 weeks of age, during bacteria gut colonization, were assessed for eligibility. Our data demonstrate that the colonization with commensal microbes, in particular, Bifidobacterium spp., of the gut causes modulation of HERVs.
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