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Related Concept Videos

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Related Experiment Video

Updated: Dec 29, 2025

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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Converging patterns of aging-associated brain volume loss and tissue microstructure differences.

Marco Taubert1, Elisabeth Roggenhofer2, Lester Melie-Garcia2

  • 1Chair for Training Science, Cognition and Action, Faculty of Humanities, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioural and Brain Sciences - CBBS, Magdeburg, Germany; Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Neurobiology of Aging
|February 10, 2020
PubMed
Summary

Aging brains show significant white matter loss, particularly in motor and executive function areas. Quantitative MRI reveals declines in myelin and iron, alongside increased free water, impacting brain structure and function over time.

Keywords:
BrainHealthy cognitive ageingIronMagnetic resonance imagingMyelinVoxel-based quantification

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Area of Science:

  • Neurobiology
  • Neuroimaging
  • Aging Research

Background:

  • Aging-associated brain diseases pose a growing socioeconomic challenge.
  • Understanding neurobiology of lifespan brain changes is crucial.
  • Quantitative magnetic resonance imaging (qMRI) offers detailed in vivo insights into brain aging.

Purpose of the Study:

  • To link morphometric findings in aging to microstructural tissue properties.
  • Investigate aging-related changes in myelin, iron, and free water content.
  • Examine these changes in a large-scale cohort (n=966, age 46-86).

Main Methods:

  • Utilized quantitative magnetic resonance imaging (qMRI) for in vivo brain analysis.
  • Analyzed a large cohort (n=966) aged 46-86 years.
  • Applied different approaches to adjust local findings for global effects to address controversies.

Main Results:

  • Confirmed age-related atrophy, myelin, and free water decreases.
  • Observed proportionally steeper declines in volume, iron, and myelin in sensorimotor and subcortical areas.
  • Reported increased free water in these regions, alongside white matter loss in frontostriatal projections.

Conclusions:

  • Demonstrated spatial overlap between volume and tissue property changes in aging.
  • Aging predominantly affects motor and executive networks through microstructural alterations.
  • Findings provide robust evidence for specific regional vulnerabilities in the aging brain.