Carbon monoxide and its donors - Chemical and biological properties
Weronika Adach1, Mateusz Błaszczyk1, Beata Olas1
1University of Lodz, Department of General Biochemistry, Faculty of Biology and Environmental Protection, Pomorska 141/143, 90-236, Lodz, Poland.
Abstract:
Carbon monoxide (CO) is an inorganic chemical compound that can bind with hemoglobin with highly toxic effects. In living organisms, it is produced endogenously during the degradation of heme by oxygenase, which occurs in three isoforms: HO-1, HO-2 and HO-3. CO can play an important role in the regulation of many physiological functions. Carbon Oxide Releasing Molecules (CORMs) are a novel group of chemical compounds capable of controlled CO release directly in tissues or organs. This release depends on concentration, pH, solvent type and temperature. The biological role and the therapeutic potential of different CORMs is not always well demonstrated. However, this mini review summarizes the various function of these compounds.
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