Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

850
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
850
Antimicrobial Proteins01:23

Antimicrobial Proteins

12.8K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.8K
Surface Membrane Barriers01:18

Surface Membrane Barriers

2.5K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.5K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

146
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
146

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Enantiomeric Resolution of Chiral Triazoles in Supercritical Fluid Chromatography.

Chirality·2025
Same author

Novel Quaternary Ammonium Derivatives Based on Apple Pectin.

Polymers·2024
Same author

Chitosan/Poly(maleic acid-<i>alt</i>-vinyl acetate) Hydrogel Beads for the Removal of Cu<sup>2+</sup> from Aqueous Solution.

Gels (Basel, Switzerland)·2024
Same author

New Quaternary Ammonium Derivatives Based on Citrus Pectin.

Polymers·2024
Same author

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase.

Pharmaceuticals (Basel, Switzerland)·2023
Same author

Bile Acid Sequestrants Based on Natural and Synthetic Gels.

Gels (Basel, Switzerland)·2023

Related Experiment Video

Updated: Dec 29, 2025

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.7K

Novel amphiphilic dextran esters with antimicrobial activity.

Magdalena Cristina Stanciu1, Dalila Belei2, Elena Bicu2

  • 1"Petru Poni" Institute of Macromolecular Chemistry, Department of Natural Polymers, Bioactive and Biocompatible Materials, Gr. Ghica Voda Alley, no 41 A, 700457, Iasi, Romania.

International Journal of Biological Macromolecules
|February 10, 2020
PubMed
Summary

Researchers created new amphiphilic dextran esters with antimicrobial properties. These novel polysaccharide derivatives show potential for various applications due to their self-assembly and biological activity.

Keywords:
1,4-disubstituted-1,2,3-triazoleamphiphilic estersantimicrobial activitydextranself-association

More Related Videos

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.8K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.2K

Related Experiment Videos

Last Updated: Dec 29, 2025

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.7K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

3.8K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.2K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Organic Chemistry

Background:

  • Polysaccharides offer a versatile platform for developing novel functional materials.
  • Amphiphilic polymers are crucial for self-assembly and drug delivery applications.
  • Functionalization of dextran can impart new properties and enhance its utility.

Purpose of the Study:

  • To synthesize novel amphiphilic dextran esters.
  • To characterize the structural and thermal properties of the synthesized compounds.
  • To investigate the self-assembly behavior and antimicrobial activity of dextran esters.

Main Methods:

  • Polysaccharide functionalization using N,N'-carbonyldiimidazole activation.
  • Copper(I)-catalyzed cycloaddition for triazole ring formation.
  • Spectroscopic (NMR, FTIR) and thermal (TGA, DSC, WAXD) characterization.
  • Dynamic light scattering (DLS) and transmission electron microscopy (TEM) for self-assembly studies.
  • Fluorescence spectroscopy for critical aggregation concentration (CAC) determination.
  • Disc-diffusion assay for antimicrobial activity assessment.

Main Results:

  • Successful synthesis of amphiphilic dextran esters containing 1,2,3-triazole moieties.
  • Comprehensive structural and thermal characterization confirmed the successful functionalization.
  • Polymers formed self-associates in aqueous solutions, with critical aggregation concentrations (CAC) ranging from 4.1-9.5 mg/dL.
  • Some dextran ester derivatives exhibited notable antimicrobial activity.

Conclusions:

  • Amphiphilic dextran esters were effectively synthesized and characterized.
  • The synthesized polymers demonstrate self-assembly capabilities in aqueous media.
  • The developed dextran esters show promising antimicrobial activity, suggesting potential therapeutic applications.