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In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while...
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Related Experiment Video

Updated: Dec 29, 2025

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Development of microemulsion based topical ivermectin formulations: Pre-formulation and formulation studies.

Surajit Das1, Sie Huey Lee1, Vernissa Dilys Chia1

  • 1Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore.

Colloids and Surfaces. B, Biointerfaces
|February 10, 2020
PubMed
Summary

New microemulsions and microemulsion gels enhance topical ivermectin delivery. These formulations show improved stability and faster in vitro release compared to Soolantra cream, offering promising therapeutic potential.

Keywords:
IvermectinMicroemulsionPermeationPhase diagramStability

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Dermatology

Background:

  • Topical ivermectin delivery faces challenges with existing formulations.
  • Developing stable and effective vehicles is crucial for enhanced therapeutic outcomes.
  • Microemulsions and microemulsion gels offer potential for improved drug solubility and skin penetration.

Purpose of the Study:

  • To formulate and characterize microemulsions and microemulsion gels for topical ivermectin delivery.
  • To evaluate the solubility, stability, and in vitro release profiles of the developed formulations.
  • To compare the performance of novel formulations against a reference product.

Main Methods:

  • Pseudo-ternary phase diagrams were constructed using tea tree oil, ethyl butanoate, surfactants, and co-surfactants.
  • Ivermectin-loaded microemulsions and microemulsion gels were formulated based on phase diagram data.
  • Formulations were characterized for droplet size, morphology (cryogenic FESEM), and stability.
  • In vitro membrane permeation studies were conducted and compared to Soolantra cream.

Main Results:

  • Stable ivermectin-loaded microemulsions with nano-droplet size (<100 nm) were successfully prepared.
  • Ethyl butanoate-based microemulsions showed optimal stability and permeation; tea tree oil-based microemulsions exhibited superior stability.
  • Microemulsion gels demonstrated enhanced stability over microemulsions.
  • All microemulsion gel formulations exhibited significantly faster in vitro ivermectin release than Soolantra cream.

Conclusions:

  • Developed microemulsions and microemulsion gels are effective vehicles for topical ivermectin delivery.
  • The novel formulations offer improved stability and enhanced in vitro drug release.
  • These findings suggest promising potential for advanced topical ivermectin therapies.