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Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
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Neutrophils in the Tumor Microenvironment
Lingyun Wu1, Sugandha Saxena1, Rakesh K Singh2
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
Advances in Experimental Medicine and Biology
|February 10, 2020
Summary
Neutrophils, abundant immune cells, significantly influence cancer progression. Targeting neutrophils offers potential for novel cancer diagnostics and therapies.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Neutrophils are critical immune cells involved in inflammation and infection response.
- They play a multifaceted role in cancer progression, including promoting angiogenesis, immunosuppression, and metastasis.
- Elevated neutrophil-to-lymphocyte ratios are increasingly recognized as potential indicators of cancer status.
Purpose of the Study:
- To explore the phenotypic and functional alterations of neutrophils within the tumor microenvironment.
- To elucidate the mechanisms by which neutrophils contribute to cancer metastasis.
- To evaluate the clinical utility of neutrophils as prognostic/diagnostic markers and therapeutic targets in cancer.
Main Methods:
- Review of current literature on neutrophil function in cancer.
- Analysis of studies investigating neutrophil-TME interactions.
- Examination of clinical data correlating neutrophil levels with cancer outcomes.
Main Results:
- Neutrophils undergo significant phenotypic and functional changes in the tumor microenvironment.
- Specific mechanisms of neutrophil-mediated cancer cell metastasis are identified.
- The neutrophil-to-lymphocyte ratio shows promise as a biomarker.
Conclusions:
- Neutrophils are key players in cancer progression and metastasis.
- Understanding neutrophil behavior in the tumor microenvironment is crucial for developing new therapies.
- Neutrophils represent a promising target for cancer diagnostics and therapeutics.
Keywords:
AngiogenesisCXCR2 ligandsIL17MetastasisNETsNLRNeutrophilNeutrophil-released proteasesPro-tumor chemokinesPro-tumor cytokinesTumor microenvironmentMore Related Videos
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