Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.7K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.7K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.8K
Metastasis02:30

Metastasis

6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
Tumor Progression02:07

Tumor Progression

7.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ratiometric Fluorescent Chemosensing for Predicting Response to Irinotecan-Based Therapies in Pancreatic Ductal Adenocarcinoma.

ACS sensors·2026
Same author

Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Nature·2026
Same author

Latency-Associated Peptide Rapidly Upregulates Neuraminidase 3 in a Profibrotic Translation-Based Positive Feedback Loop.

Cells·2026
Same author

Hospitalist Care for Unplanned Oncology Admissions: A Mixed-Method Analysis of Oncology and General Hospitalist Outcomes and Processes.

Cancer medicine·2026
Same author

Integrative Oncology Models of Care: Practice Patterns From NCCN Member Institutions.

Journal of the advanced practitioner in oncology·2026
Same author

Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in <i>Dictyostelium discoideum</i> in Response to Two Different Chemorepellents.

Cells·2026

Related Experiment Video

Updated: Dec 29, 2025

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
08:02

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

6.3K

Fibrocytes in the Tumor Microenvironment.

David Roife1,2, Jason B Fleming2, Richard H Gomer3

  • 1Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Advances in Experimental Medicine and Biology
|February 10, 2020
PubMed
Summary

Tumors resemble chronic wounds due to shared healing processes. Fibrocytes, cells aiding wound repair, may promote tumor growth and invasion, presenting a potential anticancer target.

Keywords:
BenignCancerFibroblastFibrocyteFibrosisMalignantMetastasisMicroenvironmentMonocyteMyofibroblastScarStromaTumorWound

More Related Videos

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
10:26

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Published on: October 21, 2022

2.4K
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

4.9K

Related Experiment Videos

Last Updated: Dec 29, 2025

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
08:02

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

6.3K
Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
10:26

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Published on: October 21, 2022

2.4K
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

4.9K

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Tumors share molecular and cellular processes with chronic wounds.
  • Tumor healing processes are dysregulated, promoting cancer growth and invasion.
  • Fibrocytes are crucial for wound healing, differentiating from monocytes.

Purpose of the Study:

  • To explore the role of fibrocytes in the tumor microenvironment.
  • To investigate fibrocytes as a potential target for anticancer research.

Main Methods:

  • Review of existing literature on wound healing and tumor microenvironment.
  • Analysis of cellular and molecular mechanisms involving fibrocytes.

Main Results:

  • Fibrocytes are present in the tumor microenvironment, attracted by cancer cells and immune cells.
  • Fibrocytes contribute to tumor growth, invasion, and angiogenesis.
  • Fibrocytes promote extracellular matrix production and wound contraction.

Conclusions:

  • Fibrocytes, while essential for wound healing, may support neoplastic cell survival and spread.
  • Targeting fibrocytes represents a promising avenue for future anticancer research.