Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

147
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
147
Aging01:26

Aging

519
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
519
Radical Autoxidation01:20

Radical Autoxidation

2.9K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.9K
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

4.4K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
4.4K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

147
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
147
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

174
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
174

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparable Efficacy of Medium Cut-Off Dialysis Plus HA130 Hemoadsorption and Postfilter Hemodiafiltration in Removing Protein-Bound Uremic Toxins.

Kidney medicine·2026
Same author

Visualizing the impact of quenched disorder on 2D electron Wigner solids.

Nature·2026
Same author

Interpolative Separable Density Fitting on Adaptive Real Space Grids.

Journal of chemical theory and computation·2026
Same author

Long-term potentiation and neurotransmitters expression and segregation are altered in the Metabolic Syndrome-associated dysautonomia.

PloS one·2025
Same author

Critical Gate Distance for Wigner Crystallization in the Two-Dimensional Electron Gas.

Physical review letters·2025
Same author

Light-Matter Correlation Energy Functional of the Cavity-Coupled Two-Dimensional Electron Gas via Quantum Monte Carlo Simulations.

Physical review letters·2025

Related Experiment Video

Updated: Dec 29, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.2K

Polyphenols and AGEs/RAGE axis. Trends and challenges.

Ileana González1, Miguel A Morales2, Armando Rojas1

  • 1Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, Talca, Chile.

Food Research International (Ottawa, Ont.)
|February 11, 2020
PubMed
Summary
This summary is machine-generated.

Polyphenols combat harmful advanced glycation end-products (AGEs) by inhibiting their formation and blocking receptor interactions. This review details how these compounds mitigate AGEs-related diseases, including diabetes and neurodegeneration.

Keywords:
Advanced glycationCarbonyl stressMaillard reactionPolyphenols

More Related Videos

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.7K
A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
10:30

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

7.9K

Related Experiment Videos

Last Updated: Dec 29, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.2K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.7K
A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
10:30

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

7.9K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nutritional Science

Background:

  • Advanced glycation end-products (AGEs) are implicated in diabetic complications, neurodegeneration, and cardiovascular diseases.
  • AGEs exert detrimental effects through cross-linking and interaction with the receptor for advanced glycation end-products (RAGE).

Purpose of the Study:

  • To review the beneficial actions of polyphenols in mitigating the harmful consequences of AGEs formation.
  • To elucidate the mechanisms by which polyphenols counteract AGEs-related pathophysiology.

Main Methods:

  • Literature review focusing on polyphenol mechanisms against AGEs.
  • Analysis of studies investigating polyphenol inhibition of glycation pathways and RAGE signaling.

Main Results:

  • Polyphenols inhibit reactive oxygen species (ROS) formation during glycation.
  • Polyphenols impede Schiff base, Amadori products, and dicarbonyl formation, and activate the glyoxalase system.
  • Polyphenols block AGEs-RAGE interactions and downstream cell signaling.

Conclusions:

  • Polyphenols offer a promising therapeutic strategy against AGEs-related diseases.
  • Their multifaceted actions include antioxidant effects, direct inhibition of glycation, and modulation of RAGE pathways.