Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Consideration01:22

Design Consideration

484
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
484
Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

569
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
569
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

430
Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
430
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

340
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
340
Assessment of apical radial pulse01:25

Assessment of apical radial pulse

1.2K
Apical-Radial (A-R) Pulse Assessment
The A-R pulse assessment involves simultaneous evaluation of the apical and radial pulses. When the apical and radial pulse rates vary, this assessment helps identify a pulse deficit.
Pre-Procedural Preparation
1.2K
Pharmacovigilance01:19

Pharmacovigilance

1.5K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screening Rates for Primary Aldosteronism in Resistant Hypertension: A Cohort Study.

Hypertension (Dallas, Tex. : 1979)·2020
Same author

The ongoing search for a robust clinical prediction model of ICU AKI.

Clinical nephrology·2020
Same author

Central venous pressure and the risk of diuretic-associated acute kidney injury in patients after cardiac surgery.

American heart journal·2020
Same author

Effect of Intensive vs Standard Blood Pressure Treatment Upon Erectile Function in Hypertensive Men: Findings From the Systolic Blood Pressure Intervention Trial.

The journal of sexual medicine·2019
Same author

Safety-Net Care for Maintenance Dialysis in the United States.

Journal of the American Society of Nephrology : JASN·2019
Same author

Acute Kidney Injury in Children Hospitalized With Diarrheal Illness in the United States.

Hospital pediatrics·2019
Same journal

Approach to Hyperkalemia: The Role of Diet and Pharmacological Therapies.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

High Protein Diets: What to Tell Our Patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Progressive Kidney Dysfunction and Ocular Clues: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same journal

Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
See all related articles

Related Experiment Video

Updated: Dec 29, 2025

Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS
04:40

Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS

Published on: July 30, 2020

3.2K

AKI-A Relevant Safety End Point?

Ian E McCoy1, Glenn M Chertow1

  • 1Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 11, 2020
PubMed
Summary
This summary is machine-generated.

Current acute kidney injury (AKI) definitions may not reflect patient outcomes. Future research should focus on patient-centered end points like major adverse kidney events to ensure effective therapies are not withheld.

Keywords:
AKI definitionAcute kidney injury (AKI)acute decompensated heart failure (ADHF)acute renal failure (ARF)biomarkerblood pressure controlclinical trialshemodynamicskidney damagekidney functionmajor adverse kidney events (MAKE)patient-centered outcome (PCO)prognosissafetysafety signalserum creatinine (sCr)surrogate outcometrial end point

More Related Videos

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning
06:03

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

2.8K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.3K

Related Experiment Videos

Last Updated: Dec 29, 2025

Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS
04:40

Tactile Semiautomatic Passive-Finger Angle Stimulator TSPAS

Published on: July 30, 2020

3.2K
Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning
06:03

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

2.8K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.3K

Area of Science:

  • Nephrology
  • Clinical Trials
  • Cardiovascular Medicine

Background:

  • Acute kidney injury (AKI) is frequently assessed in clinical trials, often as a safety endpoint.
  • Current AKI definitions, based on serum creatinine, may not correlate with patient-centered outcomes like dialysis or death.

Purpose of the Study:

  • To review issues with current AKI definitions.
  • To advocate for patient-centered AKI endpoints in future research.

Main Methods:

  • Review of data from randomized controlled trials.
  • Analysis of commonly used AKI definitions and their association with patient outcomes.

Main Results:

  • Some studies suggest AKI may be associated with favorable outcomes in certain contexts.
  • Nonspecific AKI endpoints may lead to withholding beneficial therapies.

Conclusions:

  • Patient-centered AKI endpoints, such as major adverse kidney events (MAKE) at 30 days or later, are crucial.
  • Adopting MAKE will improve the development and approval of beneficial therapies.