Related Experiment Video
Updated: Dec 29, 2025
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
32.3K
T2-"Low" Asthma: Overview and Management Strategies
Anne M Fitzpatrick1, Bradley E Chipps2, Fernando Holguin3
1Emory University Department of Pediatrics, Atlanta, Ga.
The Journal of Allergy and Clinical Immunology. in Practice
|February 11, 2020
Summary
Type 2-"low" asthma lacks T2 immune pathway upregulation and eosinophilic inflammation, unlike T2-"high" asthma. This review explores T2-"low" asthma definitions, features, and potential treatments.
Area of Science:
- Pulmonology
- Immunology
- Genetics
Background:
- Asthma classification has evolved beyond general symptoms to recognize distinct phenotypes.
- Type 2 (T2)-high asthma involves T2 immune pathways (IL-4, IL-13) and eosinophilic inflammation.
- T2-low asthma is characterized by the absence of these T2 features and may show reduced corticosteroid responsiveness.
Purpose of the Study:
- To define and describe the clinical and molecular characteristics of T2-low asthma.
- To explore potential mechanisms, metabolic aspects, and pediatric considerations for T2-low asthma.
- To discuss potential treatment strategies and identify key research questions for T2-low asthma.
Main Methods:
- This is a review article, synthesizing existing literature.
- The review examines definitions, clinical presentations, and molecular profiles of T2-low asthma.
- It also considers pediatric aspects and therapeutic interventions.
Main Results:
- T2-low asthma is a distinct phenotype lacking T2 immune signatures.
- This phenotype may be associated with corticosteroid resistance.
- The review outlines various facets of T2-low asthma, including its pathophysiology and clinical management.
Conclusions:
- Recognizing T2-low asthma is crucial for understanding asthma heterogeneity.
- Further research is needed to elucidate mechanisms and optimize treatments for T2-low asthma.
- Differentiated approaches may improve outcomes for patients with this asthma phenotype.
Related Concept Videos
01:30Asthma-IV: Diagnostic and Management
3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
01:30Asthma-IV: Nursing Management
3.6K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
3.6K
01:20Asthma: Pathogenesis and Management
1.1K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
01:29Asthma-I: Introduction
3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
01:24Asthma-III: Symptoms and Complications
3.2K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.2K
01:29Chronic Obstructive Pulmonary Disease-V: Management
3.0K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.0K