Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting the WASF3 Regulatory Complex in Pancreatic Cancer Using Stapled Peptides.

Biochemistry·2026
Same author

Extracellular Vesicle-Mediated Delivery of Constrained Peptides Disrupts the Pathogenic Interaction of LRRK2-FADD in Parkinson's Disease.

Journal of extracellular biology·2026
Same author

Anionic lipids direct efficient microfluidic encapsulation of stable and functionally active proteins in lipid nanoparticles.

Communications materials·2025
Same author

Development of an All-Hydrocarbon Stapled Peptide Targeting BRK1 in Triple-Negative Breast Cancer.

ACS medicinal chemistry letters·2025
Same author

Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC.

ACS chemical biology·2024
Same author

Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease.

Journal of peptide science : an official publication of the European Peptide Society·2023

Related Experiment Video

Updated: Dec 28, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.3K

Targeting Plasmodium with constrained peptides and peptidomimetics.

Leah G Helton1, Eileen J Kennedy1

  • 1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.

IUBMB Life
|February 11, 2020
PubMed
Summary

Peptide therapeutics offer a promising alternative to combat drug-resistant malaria. Research focuses on chemically constrained peptides targeting key parasite proteins to develop novel antimalarial treatments.

Keywords:
Plasmodiumconstrained peptidehydrogen bond surrogatelactam bridgemalariapeptidomimeticstapled peptide

More Related Videos

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.7K
Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

12.9K

Related Experiment Videos

Last Updated: Dec 28, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.3K
Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.7K
Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

12.9K

Area of Science:

  • Malariology
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • Malaria affects millions globally, causing hundreds of thousands of deaths annually.
  • Drug-resistant Plasmodium strains pose a significant challenge to current antimalarial therapies.
  • Small molecule inhibitors face limitations due to emerging drug resistance.

Purpose of the Study:

  • To review research on constrained peptides and peptidomimetics as antimalarial agents.
  • To explore peptide-based strategies targeting protein-protein interactions crucial for malaria parasite survival.
  • To identify novel therapeutic avenues against drug-resistant malaria strains.

Main Methods:

  • Investigating chemically constrained peptides and peptidomimetics.
  • Targeting specific protein-protein interactions essential for malaria pathogenesis.
  • Utilizing diverse synthetic methodologies for peptide development.

Main Results:

  • Peptide therapeutics show potential against malaria.
  • Targeted protein-protein interactions include Falcipain-2, CDPK1, and myosin A.
  • Diverse synthetic approaches are employed for peptide development.

Conclusions:

  • Constrained peptides represent a viable alternative to small molecules for antimalarial drug development.
  • Targeting protein-protein interactions offers a new strategy against drug-resistant malaria.
  • Integrating parasite biology with synthetic chemistry can yield novel antimalarial compounds.