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Updated: Dec 28, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

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Torpedo maculopathy: A case series - insights into basic pathology.

Doaa Kerwat¹, Omer Jamall¹, Serafeim Antonakis^1,2

¹Maidstone Hospital, Kent, UK.

European Journal of Ophthalmology

|February 11, 2020

Summary

This summary is machine-generated.

Torpedo maculopathy, a benign retinal disorder, may involve developmental anomalies of the retinal pigment epithelium. Findings suggest potential fluid accumulation over time, questioning if the condition is progressive.

Keywords:

Torpedo maculopathy benign retinal disorder cleft dysgenetic/agenetic retinal pigment epithelium hypopigmented lesion optical coherence tomography pathophysiology

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Area of Science:

Ophthalmology
Retinal Diseases
Developmental Biology

Background:

Torpedo maculopathy is a benign retinal disorder with unclear origins.
Theories suggest stable developmental anomalies of the retinal pigment epithelium (RPE).

Purpose of the Study:

To investigate the clinical presentation and potential pathophysiology of torpedo maculopathy.
To explore the role of RPE anomalies in disease progression.

Main Methods:

Case study analysis of four patients with macular torpedo lesions.
Ophthalmic examination and imaging to assess retinal structure and fluid accumulation.

Main Results:

All cases showed thin RPE and outer retina associated with torpedo lesions.
One patient exhibited subretinal and intraretinal fluid, correlating with age and potential RPE changes.

Conclusions:

Torpedo maculopathy may involve RPE dysgenesis, potentially leading to secondary fluid accumulation.
Further research is needed to determine if torpedo maculopathy is a progressive or static condition.