The vertebral column of diabetic sand rats (Psammomys obesus)

Intervertebral discs and vertebral spongiosa of diabetic and nondiabetic sand rats were investigated histologically and morphometrically. In diabetic animals, degeneration of the intervertebral discs was accelerated. Morphometrically, there was a consistent trend in the diabetics toward an attenuated bone turnover, which was, however, statistically significant only in regard to the length of the trabecular surface covered by osteoblasts. In the vertebral column of the sand rat, the tendency to osteoporosis - age-linked or diabetes-related - is reduced apparently due to the influence of local forces which promote osteogenesis.