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Brain Activations to Dyspnea in Patients With COPD
Thomas Reijnders1, Thierry Troosters2,3, Wim Janssens3,4
1Health Psychology, KU Leuven, Leuven, Belgium.
Abstract:
We compared the perception and neural processing of respiratory sensations between 20 COPD patients and 20 healthy controls by means of respiratory-related evoked potentials (RREP) in the electroencephalogram (EEG). RREPs were induced by short inspiratory occlusions while 129-channel EEG was measured. COPD patients rated the occlusions as more intense and unpleasant (p's < 0.001) and showed higher mean amplitudes for the RREP components P1 (p = 0.0004), N1 (p = 0.024), P2 (p = 0.019), and P3 (p = 0.018). Our results indicate that COPD patients demonstrate greater perception and neural processing of respiratory sensations, which presumably reflects the highly aversive and attention-demanding character of these sensations for COPD patients.
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