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ONYCHOMYCOSIS: A Review of New and Emerging Topical and Device-based Treatments

Nisrine Kawa1,2, Kachiu C Lee1,2, R Rox Anderson1,2

  • 1Drs. Kawa, Anderson, and Garibyan are with the Wellman Center for Photomedicine at Massachusetts General Hospital and the Department of Dermatology at Harvard Medical School in Boston, Massachusetts.

The Journal of Clinical and Aesthetic Dermatology
|February 11, 2020
PubMed

Insights

Onychomycosis, a difficult nail fungal infection, has limited treatment options. This review explores emerging topical therapies and device-based treatments, including lasers, for improved outcomes.

Area of Science:

  • Dermatology
  • Mycology
  • Medical Device Technology

Background:

  • Onychomycosis presents significant treatment challenges.
  • Current gold-standard systemic therapies have potential risks.
  • Existing topical treatments often yield unsatisfactory results.

Purpose of the Study:

  • To review recent advancements in topical onychomycosis treatments.
  • To evaluate the efficacy and status of novel therapeutic approaches.
  • To discuss the role of lasers and energy-based devices in nail fungal infection management.

Main Methods:

  • Review of United States Food and Drug Administration (FDA)-approved topical formulations.
  • Analysis of topical antifungal drugs in clinical trials.
  • Examination of laser and energy-based device applications for onychomycosis.
  • Assessment of combination therapies, including laser-assisted drug delivery.

Main Results:

  • Newer topical formulations offer potential alternatives to systemic treatments.
  • Device-based therapies are emerging, though standardization is pending.
  • Lasers show promise for enhancing topical treatment penetration and cosmetic improvement.

Conclusions:

  • Novel topical agents and device-based therapies represent evolving treatment strategies for onychomycosis.
  • Further research is needed to establish standardized parameters for device-based treatments.
  • Combination approaches may offer enhanced efficacy for challenging nail fungal infections.
Keywords:
Antifungalfunguslasernailonychomycosis

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