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Updated: Dec 28, 2025

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Ovarian Cancer Targeted Theranostics
Sridhar Nimmagadda1,2, Marie-France Penet2,3
1Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Abstract:
Ovarian cancer is a leading cause of death from gynecological malignancies. Although the prognosis is quite favorable if detected at an early stage, the vast majority of cases are diagnosed at an advanced stage, when 5-year survival rates are only 30-40%. Most recurrent ovarian tumors are resistant to traditional therapies underscoring the need for new therapeutic options. Theranostic agents, that combine diagnostic and therapeutic capabilities, are being explored to better detect, diagnose and treat ovarian cancer. To minimize morbidity, improve survival rates, and eventually cure patients, new strategies are needed for early detection and for delivering specifically anticancer therapies to tumor sites. In this review we will discuss various molecular imaging modalities and targets that can be used for imaging, therapeutic and theranostic agent development for improved diagnosis and treatment of ovarian cancer.
Insights
New theranostic agents offer hope for ovarian cancer patients by combining diagnostic and therapeutic capabilities for early detection and targeted treatment, improving survival rates.
Area of Science:
- Gynecological Oncology
- Molecular Imaging
- Theranostics
Background:
- Ovarian cancer is a major cause of gynecological cancer death, with poor survival rates when diagnosed late.
- Advanced-stage ovarian cancer often becomes resistant to conventional treatments, necessitating novel therapeutic strategies.
- Current diagnostic and treatment methods lack specificity, leading to suboptimal patient outcomes.
Purpose of the Study:
- To review molecular imaging modalities and targets for ovarian cancer.
- To explore the development of theranostic agents for improved diagnosis and treatment.
- To highlight strategies for early detection and targeted therapy delivery in ovarian cancer.
Main Methods:
- Review of current literature on molecular imaging in ovarian cancer.
- Analysis of potential molecular targets for imaging and therapy.
- Discussion of theranostic agent design principles and applications.
Main Results:
- Various molecular imaging techniques show promise for detecting ovarian cancer.
- Specific molecular targets are being identified for theranostic agent development.
- Theranostics offer a dual approach for simultaneous diagnosis and treatment.
Conclusions:
- Theranostic agents represent a promising frontier for advancing ovarian cancer care.
- Targeted molecular imaging and therapy can improve early detection and treatment efficacy.
- Further research into theranostic agents is crucial for enhancing patient survival and quality of life.
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